Joint CeNS Colloquium with SFB1032
Prof. Sebastian Streichan, UC Santa Barbara
30.06.2023 at 15:30
Title: Design principles of fate, form, forces and function: From embryogenesis to synthetic morphogenesis
Location: Faculty of Physics, Kleiner Physikhörsaal N020 and the talk will be streamed online via Zoom
Host: Dr. Friedhelm Serwane, Prof. Joachim Rädler
Abstract: Organ architecture is often composed of multiple concentric tissue layers. Morphogenesis folds these layers into a specific shape that is required for organ function. Genetic signals that determine cell fate have been uncovered - yet the dynamic interplay of tissue layers giving rise to specific form remains elusive. We combine multi-layer analysis of cellular dynamics on evolving surfaces with physical modeling to obtain testable quantitative descriptions of how genetic patterning controls physics to give rise to shape.
I will discuss two examples:
(I) Quantitative analysis of organogenesis in D. melanogaster reveals how genes triggers dynamic molecular mechanisms to control physical processes.
(II) A chip-based culture system enables self-organization of micro patterned stem cells into precise three-dimensional cell-fate patterns and form. This system recreates aspects of neural tube folding, and indicates basal interactions between non-neural and neural ectoderm are required for tube closure.
also see CeNS website