SFB 1032: Nanoagents for Spatiotemporal Control of Molecular and Cellular Reactions
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Publications Area B

B01

"Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration."
Authors: Christoph Schreiber, Felix J. Segerer, Ernst Wagner (B04), Andreas Roidl & J. O. Rädler.
Scientific Reports 6, Article number: 26858 (2016), doi:10.1038/srep26858, Published online:
31 May 2016

"Stability analysis of chemically modified mRNA using micropattern-based single-cell arrays"
Authors: Mehrije Ferizi, Carolin Leonhardt, Christian Meggle, Manish K. Aneja, Carsten Rudolph, Christian Plankac and J. O. Rädler.
Lab Chip, Advance Article, DOI: 10.1039/C5LC00749F-First published online 16 Jul 2015

"Phenomenological approaches to collective behavior in epithelial cell migration"
Authors: Matthias Zorn, Anna-Kristina Marel, Felix J. Segerer and J. O. Rädler.
BBA, doi:10.1016/j.bbamcr.2015.05.021, available online 29 May 2015.

"Emergence and persistence of collective cell migration on small circular micropatterns"
Authors: Felix J. Segerer, Florian Thüroff, Alicia Piera Alberola, Erwin Frey (B02), and J. O. Rädler
Phys. Rev. Lett. 114, 228102, DOI: 10.1103/PhysRevLett.114.228102 – Published 2 June 2015

"Cell Motility on Polyethylene Glycol Block Copolymers Correlates to Fibronectin Surface Adsorption"
Authors: Peter J. F. Röttgermann, Samira Hertrich, Ida Berts, Max Albert, Felix J. Segerer, Jean-François Moulin,
Bert Nickel (A07) and J. O. Rädler.
Macromolecular Bioscience, Vol. 14, Issue 12, pages 1755–1763, DOI: 10.1002/mabi.201400246, Dec. 2014

"Alignment of cell division axes in directed epithelial cell migration"
Authors: Anna-Kristina Marel, Nils Podewitz, Matthias Zorn, J. O. Rädler and Jens Elgeti
New Journal of Physics, doi:10.1088/1367-2630/16/11/115005, Volume 16 November 2014

"The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular
Contractility"

Authors: Magdalena H. Menhofer, Rebekka Kubisch, Laura Schreiner, Matthias Zorn, Florian Foerster,
Rolf Mueller, J. O. Raedler, Ernst Wagner (B04), Angelika M. Vollmar, Stefan Zahler (B08).
PLOS ONE, Volume 9, Issue 11, e112542, November 2014

"Multi-Level Kinetic Model of mRNA Delivery via Transfection of Lipoplexes"
Authors: T. S. Ligon, C. Leonhardt and J. O. Rädler.
PLOS ONE, DOI: 10.1371/journal.pone.0107148, September 19, 2014

"Flow and Diffusion in Channel-Guided Cell Migration"
Authors: A.-K. Marel, M. Zorn, C. Klingner, R. Wedlich-Söldner, E. Frey (B02) and J. O. Rädler.
Biophysical Journal, DOI: doi.org/10.1016/j.bpj.2014.07.017, Vol 107, Issue 5, p1054–1064, Sept. 2, 2014

"Arraying Cell Cultures Using PEG-DMA Micromolding in Standard Culture Dishes."
Authors: A.-K. Marel, S. Rappl, A. Piera Alberola and J. O. Rädler.
Macromolecular Bioscience, March 4, 2013; DOI: 10.1002/mabi.201200400

"Nucleic acid nanostructures for biomedical applications"
Authors: David Smith, Verena Schüller, Christian Engst, J. O. Rädler and Tim Liedl (A06).
Future Medicine, London, January 2013, Vol. 8, No. 1, Pages 105-121 , DOI 10.2217

B02

"Multistability and dynamic transitions of intracellular Min protein patterns"
Authors: Fabai Wu, Jacob Halatek, Matthias Reiter, Enzo Kingma, Erwin Frey & Cees Dekker.
Molecular Systems Biology, Volume 12, Issue 6, DOI: 10.15252/msb.20156724, June 2016

"Binary mixtures of particles with different diffusivities demix"
Authors: Simon N. Weber, Christoph A. Weber and Erwin Frey.
Phys. Rev. Lett. 116, 058301 – Published 4 February 2016

"Geometry-induced protein pattern formation"
Authors: Dominik Thalmeier, Jacob Halatek and E. Frey.
PNAS, 10.1073/pnas.1515191113-Published before print, January 6, 2016

"Emergence and persistence of collective cell migration on small circular micropatterns"
Authors: Felix J. Segerer, Florian Thüroff, Alicia Piera Alberola, Erwin Frey, and J. O. Rädler (B01).
Phys. Rev. Lett. 114, 228102, DOI: 10.1103/PhysRevLett.114.228102 – Published 2 June 2015

"Flow and Diffusion in Channel-Guided Cell Migration"
Authors: A.-K. Marel, M. Zorn, C. Klingner, R. Wedlich-Söldner, E. Frey and J. O. Rädler (B01).
Biophysical Journal, DOI: doi.org/10.1016/j.bpj.2014.07.017, Vol 107, Issue 5, p1054–1064, Sept. 2, 2014

"Effective two-dimensional model does not account for geometry sensing by self-organized proteins patterns - Supplementary document"

Authors: Jacob Halatek aund E. Frey.
PNAS, DOI:10.1073/pnas.1220971111, April 3, 2014

"GDI-Mediated Cell Polarization in Yeast Provides Precise Spatial and Temporal Control of Cdc42 Signalin"
Authors: B. Klünder, T. Freisinger, R. Wedlich-Söldner and E. Frey.
PLOS, DOI: 10.1371/journal.pcbi.1003396, December 2013

B03

"Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrase."
Authors: Philipp Heissig, Waldemar schrimpf, Philipp Hadwiger, Ernst Wagner (B04) and Don C. Lamb.
PLOS, PONE-D-16-50271R1, Feb. 2017

"Investigation of the Co-Dependence of Morphology and Fluorescence Lifetime in a Metal-Organic Framework"
Authors: Waldemar Schrimpf , Giulia Ossato , Patrick Hirschle , Stefan Wuttke and Don C. Lamb.
small 2016, 12, No. 27, 3651–3657, DOI: 10.1002/smll.201600619, Epub 2016 May 12.

“Dual Antitumoral Potency of EG5 siRNA Nanoplexes Armed with Cytotoxic Bifunctional Glutamyl-Methotrexate Targeting Ligand.”
Authors: D.J. Lee, E. Kessel, D. Edinger, D. He, P. Klein, L. Voithenberg, D. C. Lamb, U. Lächelt, T. Lehto, E. Wagner.
Biomaterials, doi: 10.1016/j.biomaterials.2015.11.004, in press (2015).

"Live-cell observation of cytosolic HIV-1 assembly onset reveals RNA-interacting Gag oligomers"
Authors: Jelle Hendrix, Viola Baumgärtel, Waldemar Schrimpf, Sergey Ivanchenko, Michelle A. Digman, Enrico Gratton, Hans‑Georg Kräusslich, Barbara Müller and Don C. Lamb.
JCB Home, 210 (4): 629-646, doi: 10.1083/jcb.20150400, 17 August 2015

"The Lateral Membrane Organization and Dynamics of Myelin Proteins PLP and MBP Are Dictated by Distinct Galactolipids and the Extracellular Matrix"
Authors: Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C. de Jonge, Don C. Lamb, Dick Hoekstra, Nicoletta Kahya and Wia Baron
PLOS One, DOI: 10.1371/journal.pone.0101834, July 8, 2014

"Native chemical ligation for conversion of sequence-defined oligomers
into targeted pDNA and siRNA carriers"

Authors: Can Yang Zhang, Petra Kos, Katharina Müller, Waldemar Schrimpf, Christina Troiber,
Ulrich Lächelt, Claudia Scholz, Don C. Lamb and Ernst Wagner (B04).
Journal of Controlled Release, pp42-50, doi:10.1016/j.jconrel.2014.02.015, April 28, 2014

"Pulsed Interleaved Excitation Fluctuation Imaging"
Authors: Jelle Hendrix, Waldemar Schrimpf, Matthias Höller and Don C. Lamb.
Biophysical Journal 105(4) 848-861, August 2013, DOI:10.1016/j.bpj.2013.05.059

B04

"Monitoring integrity and localization of modified single-stranded RNA oligonucleotides using ultrase."
Authors: Philipp Heissig, Waldemar schrimpf, Philipp Hadwiger, Ernst Wagner and Don C. Lamb (B03).
PLOS, PONE-D-16-50271R1, Feb. 2017

"Targeted siRNA Delivery Using a Lipo-Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell."
Authors: Zhang W., Müller K., Kessel E., Reinhard S., He D., Klein PM, Höhn M., Rödl W., Kempter S. and Ernst Wagner.
Adv Healthcare Mater, doi: 10.1002/adhm.201600057, 2016 Apr 24.

"Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration."
Authors: Christoph Schreiber, Felix J. Segerer, Ernst Wagner, Andreas Roidl & J. O. Rädler (B01).
Scientific Reports 6, Article number: 26858 (2016), doi:10.1038/srep26858, Published online:
31 May 2016

"DNA as Tunable Adaptor for siRNA Polyplex Stabilization and Functionalization"
Authors: Philipp Heissig, Philipp M. Klein, Philipp Hadwiger and Ernst Wagner.
Molecular Therapy—Nucleic Acids (2014) 5, e1; doi:10.1038/mtna.2016.6; 2016

Dual Antitumoral Potency of EG5 siRNA Nanoplexes Armed with Cytotoxic Bifunctional Glutamyl-Methotrexate Targeting Ligand.
Authors: D.J. Lee, E. Kessel, D. Edinger, D. He, P. Klein, L. Voithenberg, D. C. Lamb, U. Lächelt, T. Lehto, E. Wagner, Biomaterials, doi: 10.1016/j.biomaterials.2015.11.004, in press (2015).

"Tumor-targeted Delivery of Anti-microRNA for Cancer Therapy: pHLIP is Key"
Author: Ernst Wagner,
Angewandte Chemie, Int. Edition, Vol. 54, Is. 20, pag. 5824–5826, DOI: 10.1002/anie.201502146, 2015 May 11

"Twin disulfides as opportunity for improving stability and transfection efficiency of oligoaminoethane polyplexes"
Authors: Philipp M. Kleina, Katharina Müllera, Christina Gutmanna, Petra Kosa, Ana Krhac Levacica, Daniel Edingera, Miriam Höhna, Jean-Christophe Lerouxb, Marc A. Gauthierc and Ernst Wagner.
Journal of Control Release; 205:109-19. doi: 10.1016/j.jconrel.2014.12.035. Epub 2014 Dec 29, 2015 May 10

"The proto-oncogene KRAS is targeted by miR-200c"
Authors: Florian Kopp, Ernst Wagner and Andreas Roidl.
Oncotarget; 5(1):185-95, 2014 Jan 15

"Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells"
Authors: Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Vijay Kumar Ulaganathan, Annika Herrmann, Nefertiti Elnikhely, Chitra Thakur, Zhiguang Xiao, Pjotr Knyazev, Beyhan Ataseven, Rajkumar Savai, Ernst Wagner and Andreas Roidl.
Transl Oncol.;2014 Dec; 7(6): 702–711.doi: 10.1016/j.tranon.2014.09.002, Published online 2014 Dec 10.

"The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular
Contractility"

Authors: Magdalena H. Menhofer, Rebekka Kubisch, Laura Schreiner, Matthias Zorn, Florian Foerster,
Rolf Mueller, Joachim O. Raedler (B01), Ernst Wagner, Angelika M. Vollmar, Stefan Zahler (B08)
PLOS ONE, Volume 9, Issue 11, e112542, November 2014

"Native chemical ligation for conversion of sequence-defined oligomers
into targeted pDNA and siRNA carriers"

Authors: Can Yang Zhang, Petra Kos, Katharina Müller, Waldemar Schrimpf, Christina Troiber,
Ulrich Lächelt, Claudia Scholz, Don C. Lamb (B03) and Ernst Wagner.
Journal of Controlled Release, pp42-50, doi:10.1016/j.jconrel.2014.02.015, April 28, 2014

"Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration."
Authors: Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Annika Herrmann, Ernst Wagner and Andreas Roidl.
NCBI, Doi:10.1186/1476-4598-13-16, January 27, 2014

"Biomaterials in RNAi therapeutics: quo vadis?"
Author: Ernst Wagner.
Biomaterials Science, April 2013; DOI: 10.1039/c3bm60071h

"miR-200c sensitizes cancer cells to doxorubicin treatment by decreasing TrkB and Bmi expression."
Authors: Florian Kopp, Prajakta Oak, Ernst Wagner and Andreas Roidl.
PLoS ONE 7(11)2012: e50469. doi:10.1371/journal.pone.0050469

B05

"Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release"
Authors: Stefan Datz, Christian Argyo, Michael Johannes Gattner, Veronika Weiss, Korbinian Brunner, Johanna Bretzler, Constantin von Schirnding, Adriano A. Torrano, Fabio Spada, Milan Vrabel, Hanna Engelke, C Brauchle, Thomas Carell and Thomas Bein.
Nanoscale, DOI: 10.1039/C5NR08163G, 17 Feb 2016

"Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery."
Authors: S. Heidegger, Go, A. Schmidt, S. Niedermayer, C. Argyo, S. Endres, T. Bein and C. Bourquin.
Nanoscale 8 (2016) 938-948.

"A Selective Mucin/Methylcellulose Hybrid Gel with Tailored Mechanical Properties"
Authors: Constantin Nowald, Anja Penk, Hsin-Yi Chiu, Thomas Bein, Daniel Huster and Oliver Lieleg.
Macromolecular Bioscience (2016)

"Highly Efficient siRNA Delivery from Core-Shell Mesoporous Silica Nanoparticles with Multifunctional Polymer Caps."
Authors: K. Moeller, K. Muller, H. Engelke, C. Brauchle, E. Wagner and T. Bein.
Nanoscale (2015), DOI: 10.1039/C5NR06246B

Lipid Bilayer-Coated Curcumin-based Mesoporous Organosilica Nanoparticles for Cellular Delivery.
Authors: S. Datz, H. Engelke, C. v. Schirnding, L. Nguyen and T. Bein.
Microporous and Mesoporous Materials, doi:10.1016/j.micromeso.2015.12.006

A molecular nanocap activated by superparamagnetic heating for externally stimulated cargo release.
Authors: B. Ruehle, S. Datz, C. Argyo, T. Bein and J. I. Zink.
Chemical Communications (2015)

"Multifunctional polymer-capped mesoporous silica nanoparticles for pH-responsive targeted drug delivery."
Authors: S. Niedermayer, V. Weiss, A. Herrmann, A. Schmidt, S. Datz, K. Muller, E. Wagner, T. Bein and C. Brauchle.
Nanoscale 7 (2015) 7953-7964.

"Protease-Mediated Release of Chemotherapeutics from Mesoporous Silica Nanoparticles to ex Vivo Human and Mouse Lung Tumors."
S. H. van Rijt, D. A. Bölükbas, C. Argyo, S. Datz, M. Lindner, O. Eickelberg, M. Königshoff, T. Bein and S. Meiners.
ACS Nano 9 (2015) 2377-2389.

B07

"A Selective Mucin/Methylcellulose Hybrid Gel with Tailored Mechanical Properties"
Authors: Constantin Nowald, Anja Penk, Hsin-Yi Chiu, Thomas Bein, Daniel Huster and Oliver Lieleg.
Macromolecular Bioscience (2016)

"Enzymatically active biomimetic micropropellers for the penetration of mucin gels"
Authors: Deborah Walker, benjamin T. Käsdorf, Hyeon-Ho Jeong, Oliver Lieleg und Peer Fischer.
Science Advances, Vol. 1, no. 11, e1500501, DOI: 10.1126/sciadv.1500501, 11 Dec 2015

"Modulating Mucin Hydration and Lubrication by Deglycosilation and Polyethylene Glycol Binding"
Authors: Thomas Crouzier, Kathrin Boettcher, Anthony R. Geonnotti, Nicole L. Kavanaugh, Julie B. Hirsch, Katharina Ribbeck, and Oliver Lieleg
Advanced Materials Interfaces, DOI: 10.1002/admi.201500308, Published: September 25th, 2015

"A microfluidics approach to study the accumulation of molecules at basal lamina interfaces"
Authors: Fabienna Arends, Sabine Sellner, Philipp Seifert, Ulrich Gerland (A3), Markus Rehberg (B10) and Oliver Lieleg.
Lab Chip,15, 3326-3334, DOI: 10.1039/C5LC00561B, 02 Jul 2015

"The Biophysical Properties of Basal Lamina Gels Depend on the Biochemical Composition of the Gel"
Authors: Fabienna Arends, Constantin Nowald, Kerstin Pflieger, Kathrin Boettcher, Stefan Zahler (B08)
and Oliver Lieleg.
PLOS, DOI: 10.1371/journal.pone.0118090, Published: February 17, 2015

“Ion-Specific Effects Modulate the Diffusive Mobility of Colloids in an Extracellular Matrix Gel”
Authors: Fabienna Arends, Regina Baumgärtel and Oliver Lieleg.
Langmuir, December 9, 2013, DOI: 10.1021/la404016y

B08

"Influence of Surface Modifications on the Spatiotemporal Microdistribution of Quantum Dots In Vivo"
Authors: Katharina Nekolla, Kerstin Kick, Sabine Sellner, Karina Mildner, Stefan Zahler, Dagmar Zeuschner, Fritz Krombach and Markus Rehberg (B10).
Small, DOI: 10.1002/smll.201600071, Volume 12, Issue 19, pages 2641–2651, May 18, 2016

"The Biophysical Properties of Basal Lamina Gels Depend on the Biochemical Composition of the Gel"
Authors: Fabienna Arends, Constantin Nowald, Kerstin Pflieger, Kathrin Boettcher, Stefan Zahler
and Oliver Lieleg (B07).
PLOS, DOI: 10.1371/journal.pone.0118090, Published: February 17, 2015

"The Actin Targeting Compound Chondramide Inhibits Breast Cancer Metastasis via Reduction of Cellular
Contractility"

Authors: Magdalena H. Menhofer, Rebekka Kubisch, Laura Schreiner, Matthias Zorn, Florian Foerster,
Rolf Mueller, J. O. Raedler (B01), Ernst Wagner (B04), Angelika M. Vollmar, Stefan Zahler.
PLOS ONE, Volume 9, Issue 11, e112542, November 2014

B09

"Photoswitchable Fatty Acids enable Optical Control of TRPV1"
Authors: Frank, J.A.; Mironi, M.; Moshourab, R.; Sumer M.; Lewin, G.R. and Trauner, D.
Nature Communications 6, Article number:7118, doi:10.1038/ncomms8118, Published 22 May 2015

“Photoswitchable diacylglycerols enable optical control of protein kinase C.”
Authors: James A. Frank, Dmytro A. Yushchenko, David J. Hodson, Noa Lipstein, Jatin Nagpal, Guy A Rutter, Jeong-Seop Rhee, Alexander Gottschalk, Nils Brose, Carsten Schultz & Dirk Trauner.
Nature Chemical Biology 12, 755–762 (2016), doi:10.1038/nchembio.2141

“Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.”
Malgorzata Borowiak, Wallis Nahaboo, Martin Reynders, Katharina Nekolla, Pierre Jalinot, Jens Hasserodt, Markus Rehberg, Marie Delattre, Stefan Zahler (B08), Angelika M. Vollmar, Dirk Trauner & Oliver Thorn-Seshold.
Cell 162 (2), 403–411 (2015), doi: 10.1016/j.cell.2015.06.049

“A Roadmap to Success in Photopharmacology.”
Johannes Broichhagen, James A. Frank & Dirk Trauner.
Accounts of Chemical Research 48 (7), 1947–1960 (2015), doi: 10.1021/acs.accounts.5b00129

B10

 "Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo."
Authors:Rehberg M, Nekolla K, Sellner S, Praetner M, Mildner K, Zeuschner D and Krombach F.
Small, doi: 10.1002/smll.201503606, 2016 Feb 8

"A microfluidics approach to study the accumulation of molecules at basal lamina interfaces"
Authors: Fabienna Arends, Sabine Sellner, Philipp Seifert, Ulrich Gerland (A3), Markus Rehberg and Oliver Lieleg (B7).
Lab Chip,15, 3326-3334, DOI: 10.1039/C5LC00561B, 02 Jul 2015

"DNA nanotubes as intracellular delivery vehicles in vivo"
Authors: Sabine Sellner, Samet Kocabey, Katharina Nekolla, Fritz Krombach, Tim Liedl (A06) and Markus Rehberg.
Biomaterials, Volume 53, Pages 453–463, doi:10.1016/j.biomaterials.2015.02.099, Published: June, 2015

"Label-free determination of hemodynamic parameters in the microcirculaton with third harmonic generation microscopy"
Authors: Dietzel S, Pircher J, Nekolla AK, Gull M, Brändli AW, Pohl U and Rehberg M..
PLoS One; 9(6):e99615. doi: 10.1371/journal.pone.0099615. eCollection 2014; 2014 Jun 16

 

B12

"Physical limits to Biochemical Sensing in Disordered Fiber Networks "
Authors: Chase Broedersz and Ned S. Wingreen.
Nature, NCOMMS-16-20780D, accepted Jun 2017