Nanoagents for controlled manipulation of cell-ECM interaction
Collective cell invasion and cell migration are determined by cell-ECM interactions. To study these processes we will thus develop tools to manipulate the matrix using structuring techniques such as alignment via shear flow induced by magnetic beads or surface acoustic waves. Furthermore, we will design optogenetic constructs to control cell behavior. We will then apply those tools to investi-gate single cell migration and collective invasion and will establish a mechanical model for these processes in collaboration with theoretical modeling (B12).