Controlling cellular function by structured surfaces: “Artificial angiogenesis”
We will combine the use of structured surfaces and hydrogels in order to better understand the morphogenetic processes during angiogenesis. The unifying concept will be the use of pho-toswitches for spatio-temporal control of cell migration and pattern formation. Our approaches ena-ble us to investigate transitions from single cell to collective migration, and to analyse the impact of mechanical cues for endothelial cell decision making. A special focus will be set on the influence of mechanics on transcriptional regulation (e.g. the role of actin for transcription).